The way that Avanafil in Avana prolongs the effects of cGMP is by blocking the activity of phosphodiesterase type 5.  This promotes more blood flow into the penile arteries and makes an erection easier by allowing the blood vessels to widen and the smooth muscles of the penis to relax.  Crucially, sexual stimulation is still required to start the production of nitric oxide and the erection process that follows; tadalafil does not immediately create an erection.

By promoting better urine flow and relaxing the smooth muscles of the bladder and prostate, Avana can also be used to treat the symptoms of benign prostatic hyperplasia (BPH).  Additionally, it can be used to improve exercise capacity by lowering pulmonary vascular resistance and dilatation of the pulmonary arteries, which can help treat pulmonary arterial hypertension (PAH).

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